As the area of computerized, high-fidelity medical simulation training has evolved, a new approach has developed centered on an offering of course work in interdisciplinary teams-based learning. This article compares the varied types of team-based training offered at simulation centers in educational institutions and healthcare system-based centers in order to identify how this learning style impacts the simulation spaces we design. The research data is drawn from journal publications regarding team-based simulations and the self-published course offerings and yearly reports of both educational and hospital-based simulation centers. Interdisciplinary learning in simulation is currently more prevalent in healthcare system settings, but has lagged in higher education settings. For students training in health science disciplines, much can be gained by “training the trainers” to provide cross-discipline simulation experiences in higher education settings. As simulation training continues to evolve at a rapid pace, architects and designers will need to future-proof their designs through flexibility.